Protein Details: Potassium voltage-gated channel subfamily H member 1
Protein ID
ICDB_Pro_1023
Protein Name
Potassium voltage-gated channel subfamily H member 1
Gene Name
Kcnh1; Eag
Organism
Mus musculus (Mouse)
Length
989 amino acids
AlphaFoldDB
AF-Q60603-F1-model_v4.pdb
Function
Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel . Channel properties are modulated by subunit assembly. Mediates IK(NI) current in myoblasts. Involved in the regulation of cell proliferation and differentiation; in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (By similarity)
Sequence
Ligand Binding
Binding Site
Disease
Location
Detected in brain (at protein level). Highly expressed in olfactory bulb. Detected in brain cortex; hippocampus; brain stem; striatum; thalamus; hypothalamus and spinal cord.
DOI ID
10.1073/pnas.91.8.3438; 10.1126/science.1112014; 10.1101/gr.2596504; 10.1074/jbc.m109.016337; 10.1016/j.cell.2010.12.001; 10.1016/j.febslet.2012.07.055; 10.1093/hmg/ddt076; 10.1113/jphysiol.2014.281600; 10.1016/j.jmb.2012.06.025; 10.1038/nature12487; 10.1371/journal.pone.0059265; 10.1016/j.str.2016.07.020
RefSeq
NP_034730.1